Effect of acenocumarol and aspirin on platelet function, markers of thrombinemia, and intracardiac thrombosis in patients with atrial fibrillation

Patients with atrial fibrillation taking either indirect anticoagulant acenocumarol or most often prescribed antiaggregant aspirin were followed for 1 year. The results have shown that therapy with acenocumarol lowers content of D-dimer, prevents formation and promotes lysis of left auricular thrombi and lowers risk of development of ischemic stroke in patients with atrial fibrillation and high risk of thromboembolism. Therapy with aspirin in a dose providing maximal suppression of platelet function, does not lower D-dimer levels, does not promote lysis of left auricular thrombi and is inferior to acenocumarol in prevention of ischemic stroke.


Kardiologiia. 2007;47(6):31-6.
[Article in Russian]


Zharkova TV, Ataullakhanova DM, Bykova ES, Kropacheva ES, Dobrovol'skii AB, Titaeva EV, Panchenko EP.
A.L. Myasnikov Institute of Clinical Cardiology, ul. Tretiya Cherepkovskaya, 15a, 121552 Moscow, Russia.