Paraneoplastic syndromes with neuro-ophthalmologic manifestations may involve the central nervous system, cranial nerves, neuromuscular junction, optic nerve, uvea, or retina. Most of these disorders are related to immunologic mechanisms presumably triggered by the neoplastic expression of neuronal proteins. Accurate recognition is essential to appropriate management.

Ko MW, Dalmau J, Galetta SL.

Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA. melissaw.ko@uphs.upenn.edu